A. No. Server 2008 and Server 2008 R2 can use either IPv4 or IPv6, and it's safe to disable one of them.
- Hand-On IPv6 Lab Setup
- Supporting IPv6 in Your Windows Server 2008 Environment
- Q. How do I enable jumbo frames?
- IPv6: No Sticks, Just Carrots
Check out hundreds more useful Q&As like this in John Savill's FAQ for Windows. Also, watch instructional videos made by John at ITTV.net.