A. Yes. It's possible for a single Hyper-V host to have some VMs that are highly available using failover clustering and some that aren't clustered. You should take care, however, not to place non-clustered VMs on cluster storage because doing so can cause detection problems when the host starts and the VMs are removed from Hyper-V Manager. System Center Virtual Machine Manager won't let you create non-clustered VMs on a Hyper-V node that's part of a cluster, you have to use Hyper-V Manager.

Related Reading:

Check out hundreds more useful Q&As like this in John Savill's FAQ for Windows. Also, watch instructional videos made by John at ITTV.net.