By default, Outlook, Exchange Client, and other programs will save attachments and messages and files in the /personal folder of the user profile. Beside making the profile bigger, taking longer to load, it is better to centralize user files. Edit (while the user is not logged on):

HKEY_USER\<SID>\Software\Microsoft\Windows\Current Version\\Explorer\User Shell Folders\Personal

and change the path to the user home directory (%HOMEDRIVE%%HOMEPATH% will work).

To modify this for new (not yet created) users, select the HKEY_USERS hive and Load Hive. Navigate to

%SYSTEMROOT%\Profiles\Default User\ntuser.dat

When prompted for a Key Name, type JSI. Select the JSI key and edit:

JSI\Software\Microsoft\Windows\Current Version\\Explorer\User Shell Folders\Personal

Change the value to %HOMEDRIVE%%HOMEPATH%. Select the HKEY_USERS\JSI key and Unload Hive.