If you experience multi-minute delay when opening RPC-Aware applications, including the initial load of your desktop, you may have set the StartUp type of the Remote Procedure Call (RPC) service to Manual or Disabled. The RPC Locator service may also be set to Automatic.

Use Control Panel / Services to set the StartUp type of the RPC Service to Automatic and set the startup type of the RPC Locator to Manual. Start the RPC Service.