A. The best way is to create a shortcut to the 16 bit application, then right click on the shortcut and select properties. Click on the shortcut tab and check the box "Run in separate memory space". This will make the app run in its own VDM (Virtual Dos Machine) with its own memory space. This improves performance and system stability as one 16 bit app can no longer effect another's.

An application can also be forced to run in its own memory space using:
start /separate <application name>